DiVerential avian and human tuberculin skin testing in non-tuberculous mycobacterial infection

Objective—To determine the sensitivity of diVerential avian and human delayedtype hypersensitivity skin testing in the diagnosis of non-tuberculous mycobacterial lymphadenitis. Method—Retrospective review of all patients with culture proved nontuberculous mycobacterial lymph node infections who also had diVerential avian and human skin testing performed over a 10 year period from 1986 to 1996. Results—One hundred and twenty four patients had non-tuberculous mycobacteria isolated from lymph nodes over this period, 59 of whom had diVerential skin testing performed. The sensitivity of a response of > 10 mm to the avian precipitin was 58 of 59. No patient had both a negative human and avian Mantoux. The sensitivity of the human Mantoux alone for diagnosing non-tuberculous mycobacterial infection was 81% for a response of > 5 mm and 66% for > 10 mm. Ten patients had a 0 human response. Fifty five of the 59 patients had an avian response at least 2 mm greater than the human response. Conclusion—The avian Mantoux is a very sensitive method of diagnosing nontuberculous mycobacterial infection in children. The human Mantoux is not sensitive enough to be used alone as a surrogate to diagnose non-tuberculous mycobacterial infection. (Arch Dis Child 1999;80:377–379)